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Table 1 of the Supplement provides a complete list of variables with categorizations).
These variables were obtained from the Danish Medical Birth Registry, which includes information on the parents and the newborn, pregnancy, date of birth, multiple births, gestational age, and vital status and other physical characteristics of the newborn (13).
We conducted a nationwide cohort study of all children born in Denmark of Danish-born mothers from 1 January 1999 through 31 December 2010.
We sourced the study cohort from the Danish Civil Registration System, which assigns a unique personal identification number to all people living in Denmark and keeps track of basic demographic information for each individual (8).
This unique identifier is used in all other national registries and allows for individual-level linkage of health-related information, including vaccinations and autism diagnoses.
The Danish childhood vaccination program is voluntary and free of charge.
Another criticism has been that MMR is associated with a regressive form of autism, leading to a clustering of cases with onset shortly after MMR vaccination (7).
We evaluate the risk for autism after MMR vaccination in specific periods in detail.
Of these, 2 cohort studies and 4 case–control studies specifically addressed MMR and autism, all reporting no association.
The DTa P-IPV/Hib vaccine is offered in 3 doses at 3, 5, and 12 months. General practitioners administer all childhood vaccinations and are reimbursed when reporting these to the National Board of Health; these reports are included in the Danish National Health Service Register (9).
We obtained individual-level information on MMR1 and MMR2 vaccinations and other childhood vaccinations administered in the first year of life.
From the Danish Civil Registration System, we obtained parental links to identify siblings (defined as common father and mother) for each cohort child.
Cases of autism among siblings were identified similarly to the main study outcome.
It adds to previous studies through significant additional statistical power and by addressing hypotheses of susceptible subgroups and clustering of cases.