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While each of these medications is useful in the treatment of heroin addiction, a combination of the two drugs may be more effective than either medication alone.The purpose of this study is to compare the effectiveness of naltrexone, guanfacine, and a combination of naltrexone and guanfacine at reducing drug relapse in heroin addicts.Heroin addiction is a serious health problem with no available medical treatment for preventing relapse.Naltrexone is a medication that is currently used to treat substance addiction.In contrast with other psychiatric illnesses, the presence of awareness appears to be related to the passing of time and to the worsening of the illness. Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study. Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text Lahmeyer, H. Methodologies to improve the insight of patients should, therefore, be targeted more directly on patients early in their history of heroin dependence, because the risk of lack of insight is greatest during this period. Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text Kuepper, R., van Os, J., Lieb, R., Wittchen, H. Naltrexone is a medication that is currently used to treat drug and alcohol addiction.

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An impaired level of insight has been suggested in psychiatry. In psychotic disorders, a poor degree of insight has been associated with a poorer course of the illness and non-compliance with treatment that is necessary for patients (Husted, 1999). Unexpectedly, deficits in insight have not been found to be more common and severe in patients with schizophrenia than in those with bipolar disorder – a finding that has strong clinical, theoretical, and nosological implications (Pini et al., 2001). Recent neuroscientific evidence suggests that the denial of problems related to drug use may be associated with alterations in various brain networks that contribute to insight. HAIS (Hanil Alcohol Insight Scale): validation of an insight-evaluation instrument for practical use in alcoholism.

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This integrated model includes the insula, which is involved in introception, self-awareness, and drug craving; the anterior cingulate, which is involved in behavioral monitoring and response selection; and the frontal and dorsal striatum, which is involved in automatic habit formation and self-awareness (Verdejo-Garcia and Perez-Garcia, 2008; Goldstein et al., 2009). Follow-up evaluations will occur 3 and 6 months following the end of treatment.